![]() ![]() Indications for use: useful adjunct for the relief of skeletal muscle pain due to reflex spasm due to local pathology spasticity due to upper neuron disorders: (cerebral palsy, and paraplegia) Mechanism of action: potentiates the effects of GABA and other inhibitory transmitters Does NOT interfere with calcium entry at the cell surface as with Calcium Channel Blockers.ĭose: titrate slowly from 25mg daily for 1 week, to a maximum of 100mg four times a dayĪdverse effects: hepatotoxicity- most common in women over 35 years of age. Mechanism: ?Blocks ryanodine channel, which inhibits calcium release, thus reducing muscle contraction. Malignant hyperthermia prevention or management (from general anesthesia).Spasticity due to upper motor neuron disorders (spinal cord injury, cerebral palsy, multiple sclerosis).Watch for drowsinessĭANTROLENE (Dantrium®)? available as 25mg, 50mg and 100mg caps (1974) Patient Educations: discontinue very slowly. Frequent urge to urinate or painful urination.May cause constipation, nausea and headache.Drowsiness, dizziness and fatigue, hypotension.Drug is also given intrathecally.Īdverse effects: do not discontinue abruptly to reduce risk of seizures ![]() Dose range 40-80mg per day.? Some patients may require over 80mg/day. Mechanism of action: Inhibits spinal reflexes structural analog of gamma-aminobutyric acid (GABA)ĭosage: 10mg three times daily, may be titrated upward until desired response. for spasticity of cerebral origin and spinal cord origin.for signs and symptoms of spasticity resulting from multiple sclerosis.Dose cautiously if creatinine clearance?Monitor liver function at baseline, 3 months, and 6 months, then periodically or as clinically indicated.Food affects absorption, and affects tablets and capsules differently.Effect is short-lived (3 to 6 hours) reserve for time relief most important.May cause withdrawal and rebound hypertension, tachycardia, and hypertonia. Withdrawal syndrome: hypertension, tachycardia, hypertoniaĭrug monitoring: Taper slowly for patients on high doses for long periods.Ciprofloxacin and fluvoxamine (Luvox®) contraindicated due to increased tizanidine levels.? This is a major drug interaction that should not be recklessly overridden.? Ciprofloxacin can increase tizanidine levels from 7-10 fold.Hepatotoxicity (usually reversible, rarely fatal). ![]() Hypotension (20% decrease in blood pressure).Drug interactions: interacts with oral contraceptives, because tizanidine clearance is reduced by 50%.? Avoid use with other CYP1A2 inhibitors (e.g., cimetidine, oral contraceptives).Because of the short duration of effect, treatment should be reserved for those daily activities when relief of spasticity is most important. Indications for use: short term drug indicated for the management of spasticity. Tizanidine is a structural analog of clonidine. Reduces facilitation of spinal motor neurons. It has no direct effect on skeletal muscle fibers. It reduces spasticity by increasing presynaptic inhibition of motor neurons and inhibiting pre-synaptic release of nor-epinephrine. Mechanism of action: Tizanidine is an alpha-2 receptor agonist. The effect peaks at 1-2 hours and dissipates in 3 to 6 hours TIZANIDINE ? approved:1996ĭosage: start with 4mg, increase gradually in 2 to?4mg steps.? May repeat every 6-8 hours. Contraceptive Care Specialty Pharmacistĭrugs used to treat CENTRAL ACTING SPASTICITY:.Pharmacy Technician Enhanced Training: Integrative Pharmacy.Pharmacy Technician Enhanced Training: Controlled Substance Diversion Prevention.Integrative Pharmacy Specialist - Level II.Pharmacy Technician Enhanced Training: Medication History Essentials.Pharmacy Technician Enhanced Training: Medication Therapy Management.Pain Management Specialty Pharmacist: Managing Opioids.Pain Management Specialty Pharmacist: Ancillary and Adjunctive Pain Management.Pain Management Specialty Pharmacist: Non-Opioid Pain Management.Pharmacy Technician Enhanced Training: Immunization.Pharmacy Technician Enhanced Training: Regulatory Compliance.Hands-on Diabetes: A Practical Way to Manage Diabetes.Long-Acting Injectable Specialty Pharmacist. REJECTION REGION CALCULATOR F VERIFICATION
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